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New nanoarchitectonics to enhance cell-adhesion with quatsomes

ICMAB researchers have participated in a study to create a versatile platform based on hierarchically nanostructured cell-adhesion peptides using quatsomes, which opens new possibilities for tissue engineering. The study, published in ACS Appl. Mater. Interfaces is a collaboration of three CIBER-BBN groups at ICMAB, IQAC (both CSIC) and IBEC.

25 January 2023

Researchers from the Nanomol Group at ICMAB-CSIC and CIBER-BBN, have observed a dramatically enhanced cell adhesion on new hierarchical nanoarchitectionics using their well known quatsomes nanovesicles combined with cell-adhesion (RGD) peptides. The tripeptide Arg-Gly-Asp (RGD) is the most common peptide responsible for cell adhesion. Now, this new study presents the impact of its hierarchical nanostructure on cell-adhesion.

Integration of quatsomes

Tissue engineering pursues the development of biological substitutes to restore damaged organs or tissues, or to maintain their normal function. The newer approach is to combine appropriate cells and growth factors with a scaffold that supports the tissue or organ and provides the necessary conditions and environment for adequate cell regulation and adequate delivery of bioactive growth and adhesion factors, so that cells form the new tissue with its proper structure and function.

Researchers explored the integration of quatsomes nanovesicles with RGD peptides, and studied their properties once anchored to a surface. The team developed a versatile platform based on quatsomes as an effective nanoscopic building block to achieve hierarchical nanostructures of the RGD peptide, which were further anchored to a gold substrate. The resulting hierarchical nanoarchitectonic surfaces dramatically enhanced cell adhesion.

These findings open many possible pathways for the understanding of cell behaviour and improve the performance of clinical applications like implants and tissue engineering.

The synthesis of RGD derivatives was performed at NANBIOSIS U3 “Synthesis of peptides unit” of CIBER-BBN at IQAC−CSIC, and the design and characterization of quatsomes was done at U6 of NANBIOSIS “Biomaterial Processing and Nanostructuring Unit” of CIBER-BBN at ICMAB-CSIC.

Reference article:

Hierarchical Quatsome-RGD Nanoarchitectonic Surfaces for Enhanced Integrin-Mediated Cell Adhesion
Marc Martínez-Miguel, Miquel Castellote-Borrell, Mariana Köber, Adriana R. Kyvik, Judit Tomsen-Melero, Guillem Vargas-Nadal, Jose Muñoz, Daniel Pulido, Edgar Cristóbal-Lecina, Solène Passemard, Miriam Royo, Marta Mas-Torrent, Jaume Veciana, Marina I. Giannotti, Judith Guasch, Nora Ventosa, and Imma Ratera.
ACS Appl. Mater. Interfaces 2022, 14, 42, 48179–48193
DOI: 10.1021/acsami.2c10497

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