ICMAB researcher Nieves Casañ-Pastor is co-author of the chapter on nanostructured electroactive materials.
The authors of Chapter 5 (pages 99-125) titled "Nanostructured Electroactive Materials with Large Charge Capacity: Direct Field Electrostimulation Through Connected and Non-connected Electrodes" are Ann M. Rajnicek, Cristina Suñol and ICMAB researcher at the Solid State Chemistry (SSC) group, Nieves Casañ-Pastor.
The book "Engineering Biomaterials for Neural Applications: Targeting Traumatic Brain and Spinal Cord Injuries" is published by Springer, and discusses past and present advances on the design and development of engineered materials for neural applications. The book employs traumatic brain and spinal cord injuries as concrete scenarios for neural actuation, such as recording, stimulation, repair, and reconnection, and addresses a broad audience of clinicians working on neural diseases and scientists studying materials for neural recording and/or repair.
Electric field stimulation protocols depend on the electrode material used, but the material characteristics are often not considered or sufficiently described for optimization. Furthermore, charge capacity is considered only in capacitor-like systems, without taking into account that intercalation materials offer an internal faradaic charge delivery advantage, with substantially less risk for biological systems.
This chapter describes new materials with high charge capacities, appropriate electric field protocols for using them, and examples of neural cultures that can be used to elucidate the biological effects of fields.
Mammalian neurons, neuron–astrocyte co-cultures, and amphibian spinal neurons are used in vitro, often as scratch wound models, to assess their potential for stimulating tissue repair. Importantly, remote control of dipoles induced in conducting implanted materials is shown to be a new promising approach and a breakthrough.
To be continued!
Engineering Biomaterials for Neural Applications. Targeting Traumatic Brain and Spinal Cord Injuries
Chapter 5 (pages 99-125): Nanostructured Electroactive Materials with Large Charge Capacity: Direct Field Electrostimulation Through Connected and Non-connected Electrodes
Ed. Lopez-Dolado, Serrano MC, Springer Nature.
In press. 11/04/2022 release. Online available ,
The present work has been financed by the Ministry of Science of Spain (MAT2015-65192-R and RTI2018-097753-B-I00), Fundació Marató TV3 (110130/31), Severo Ochoa Program (SEV-2015-0496 and CEX2019-000917-S) and EU grant FP6-2004-NEST-C1 028473. The authors thank J. Oró and F. Sandiumenge (ICMAB) and R. Arenal (INA) for TEM and HRTEM studies.