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Surface-Bound Gradient Deposition of Protein Nanoparticles for Cell Motility Studies

Surface-Bound Gradient Deposition of Protein Nanoparticles for Cell Motility Studies

Scientific Highlights Biomaterials and materials for drug delivery, therapy, diagnostics and sensing 06 November 2018 229 hits jags

Witold I. TatkiewiczJoaquin Seras-FranzosoElena Garcia-FruitósEsther VazquezA.R. KyvikJudith GuaschAntonio Villaverde,Jaume Veciana*, and Imma Ratera*ACS Appl. Mater. Interfaces201810 (30), pp 25779–25786

DOI: 10.1021/acsami.8b06821

A versatile evaporation-assisted methodology based on the coffee-drop effect is described to deposit nanoparticles on surfaces, obtaining for the first time patterned gradients of protein nanoparticles (pNPs) by using a simple custom-made device. Fully controllable patterns with specific periodicities consisting of stripes with different widths and distinct nanoparticle concentration as well as gradients can be produced over large areas (∼10 cm2) in a fast (up to 10 mm2/min), reproducible, and cost-effective manner using an operational protocol optimized by an evolutionary algorithm. The developed method opens the possibility to decorate surfaces “a-la-carte” with pNPs enabling different categories of high-throughput studies on cell motility.

 

Related Topics: Biomaterials and materials for drug delivery, therapy, diagnostics and sensing

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