SOMMA
  • SCIENTIFIC HIGHLIGHTS

Frontispiece: Small-Molecule Kinase-Inhibitors-Loaded Boron Cluster as Hybrid Agents for Glioma-Cell-Targeting Therapy

Frontispiece: Small-Molecule Kinase-Inhibitors-Loaded Boron Cluster as Hybrid Agents for Glioma-Cell-Targeting Therapy

Scientific Highlights Biomaterials and materials for drug delivery, therapy, diagnostics and sensing 28 August 2017 1894 hits jags

Marcos Couto, Ignacio Mastandrea, Dr. Mauricio Cabrera, Dr. Pablo Cabral, Prof. Dr. Francesc Teixidor, Dr. Hugo Cerecetto, Prof. Dr. Clara Viñas, Chemistry, 12 July 2017, DOI: 10.1002/chem.201783962

Hybrid anilinoquinazoline-icosahedral boranes with anti-glioma activity have been developed. It is is proposed that once the compound reaches the malignant cell, the presence of some transmembrane tyrosine kinase receptors, overproduced by unhealthy cell, provokes its accumulation in the tissue enriching with boron for further BNCT. Both structural motifs, anilinoquinazolinyl and icosahedral boron clusters, are connected using 1,3-dipolar cycloaddition or Sonogashira cross-coupling processes.

For more information, see the Communication by Clara Viñas et al. on https://doi.org/10.1002/chem.201701965 page 9233 ff.

 

Related Topics: Biomaterials and materials for drug delivery, therapy, diagnostics and sensing

Also on ICMAB...

Search

Your experience on this site will be improved by allowing cookies Cookie Settings