logo icmab ochoa 02 01 logo icmab ochoa 02 01
  • SCIENTIFIC HIGHLIGHTS

Boron Clusters as a Platform for New Materials: Synthesis of Functionalized o-Carborane (C2B10H12) Derivatives Incorporating DNA Fragments

Imagen1

Slawomir Janczak, Prof. Agnieszka Olejniczak, Sandra Balabańska, Prof. Marcin K. Chmielewski, Dr. Marius Lupu, Prof. Clara Viñas, Prof. Zbigniew J. Lesnikowski, Chemistry, Volume 21, Issue 43, October 19, 2015, Pages 15118–15122. DOI: 10.1002/chem.201502822

 


A synthetic strategy for functionalization of the three vertices of o-carborane and the attachment of the obtained triped to the solid support was developed. Further functionalization of the triped with short DNA sequences by automated DNA synthesis was achieved. The proposed methodology is a first example of boron cluster chemistry on a solid support opening new perspectives in boron cluster functionalization.

Related Topics: Biomaterials and materials for drug delivery, therapy, diagnostics and sensing

Also on ICMAB...

Search